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化浪百科

氯噻酮

英文名稱:Chlorthalidone

氯塞酮

英文別稱:2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide; 2-Chloro-5-(1-hydroxy-3-oxoisoindolin-1-yl)benzenesulfonamide;

CAS : 77-36-1 精確質量 : 338.01300
分子式 : C14H11ClN2O4S logP : 3.03410
分子量 : 338.76600 PSA : 117.87000
化浪參考價: ¥34600.00

化合物簡介

Chlortalidone (INN/BAN) or chlorthalidone (USAN) is a diuretic drug used to treat hypertension, originally marketed as Hygroton in the USA. It is described as a thiazide diuretic (or, rather, a thiazide-like diuretic because it acts similarly to the thiazides but does not contain the benzothiadiazine molecular structure). Compared with other medications of the thiazide class, chlortalidone has the longest duration of action but a similar diuretic effect at maximal therapeutic doses. It is often used in the management of hypertension and edema.
Unlike loop diuretics, chlortalidone efficacy is diminished in patients with certain renal diseases (e.g. chronic renal disease). A clinical trial (ALLHAT) in 2002 compared chlortalidone to doxazosin in the treatment of high-risk hypertensive patients. In this study, only chlortalidone significantly reduced the risk of combined cardiovascular disease events, especially heart failure, when compared with drugs such as doxazosin. Chlortalidone was approved by the FDA in 1960. The ALLHAT study conclusions showed that there was no significant difference in all-cause mortality, fatal heart disease, or non-fatal myocardial infarction when chlortalidone was compared with lisinopril or amlodipine but did show decreased rates of heart failure after 6 years when compared with amlodipine and decreased rates of cerebrovascular disease after 6 years when compared with lisinopril leading the study conclusions to say that thiazide-type diuretics are preferred first-step in antihypertensive therapy.
In terms of activity, chlorothalidone is very similar to hydrochlorothiazide and is used as an independent drug or in combination with other antihypertensive agents for lowering arterial blood pressure, and also as an adjuvant drug for treating edema caused by cardiac insufficiency and renal irregularities, including nephrotic syndrome.

物化性質

外觀與性狀:白色至淡黃色-白色結晶粉末無氣味的

密度:1.601g/cm3

熔點:265-267ºC (dec.)

折射率:1.694

穩定性:Stable under normal temperatures and pressures.

儲存條件:2-8ºC

安全信息

安全說明:S22; S24/25

海關編碼:2935009090

合成路線

毒性

暫無數據

圖譜

暫無

MSDS

暫無

上下游產品

上游產品 總計: 11查看更多
下游產品 總計: 11查看更多

海關數據

國家名稱 海關編碼 海關數據更新時間
中國 2935009090 2019-03
美國 2935009500 2019-03
印度 29350090 2019-03
歐盟 29350090 2019-03
英國 2935009090 2019-03
日本 293500000 2019-03
韓國 2935009090 2019-03
加拿大 2935000000 2019-03
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